W. Kim

Detection of clade 2.3.4.4b highly pathogenic H5N1 influenza virus in New York City

The paper detects H5N1 clade 2.3.4.4b influenza viruses in urban birds in New York City and highlights the urban animal-human interface as a potential zoonotic risk.

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription

This study shows how phosphorylation of the CTD regulates condensate formation and alternative splicing across species.

Tapping into the native Pseudomonas Bacterial Biofilm Structure by High-Resolution 1D and 2D MAS solid-state NMR

This study uses high-resolution 1D and 2D MAS ssNMR to characterize native Pseudomonas fluorescens biofilms without isotope labeling, identifying chemical sites and distinguishing protein and polysaccharide components.

A culture-based approach to study ecological interactions among the microbial species of the human scalp.

This study develops an in vitro model to examine ecological interactions among three scalp microbiota species, finding that S. epidermidis suppresses others, while C. acnes exploits M. restricta.

Intervertebral Disc Elastography to Relate Shear Modulus and Relaxometry in Compression and Bending

This study relates shear modulus and relaxometry in intervertebral discs under compression and bending to assess degeneration.

Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination

This study tracks the spatiotemporal dynamics of human T follicular helper (TFH) cells after influenza vaccination, showing clonal expansion, phenotypic changes, and lineage-specific responses over two years.

Phylogenetic and functional analyses of N6-methyladenosine RNA methylation factors in the wheat scab fungus Fusarium graminearum

This study investigates m6A RNA methylation factors in Fusarium graminearum, identifying copy number variations and functional roles of MTA1 in conidial germination and hyphal branching.

Telomeric repeat evolution in the phylum Nematoda revealed by high-quality genome assemblies and subtelomere structures

The paper analyzes telomeric repeat motifs in nematodes using genome assemblies and subtelomere structures to reveal evolutionary changes in TRMs.

Immature myeloid cells are indispensable for intestinal regeneration post irradiation injury

This study shows that immature myeloid cells (IMCs) are essential for intestinal regeneration after irradiation injury, driven by microbial signals and promoting epithelial repair through PGE2 production.

Physics of sliding on water predicts morphological and behavioral allometry across a wide range of body sizes in water striders (Gerridae)

The paper models sliding physics on water to predict morphological and behavioral allometry in water striders across body sizes, confirming predictions with species observations.

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

Spatial structure formation by RsmE-regulated extracellular secretions in Pseudomonas fluorescens Pf0-1

This study shows that RsmE-regulated secretions in Pseudomonas fluorescens Pf0-1 create and protect low-density spaces, with biosurfactant gacamide A defining genotypic boundaries.

Hexokinase 1b is a novel target for non-small-cell lung cancer

This study identifies HK1b as a novel therapeutic target in NSCLC by showing its role in glycolysis, tumor progression, and cisplatin resistance.

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

Identification of cyclic-di-GMP-modulating protein residues by bi-directionally evolving a social trait in Pseudomonas fluorescens

This study identifies c-di-GMP-modulating residues in Pseudomonas fluorescens by evolving social traits and analyzing mutations affecting c-di-GMP production.

Generalized Michaelis-Menten rate law with time-varying molecular concentrations

This paper generalizes the Michaelis-Menten rate law to account for time-varying molecular concentrations by introducing the effective time-delay scheme (ETS).

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.

Deep learning redesign of PETase for practical PET degrading applications

This paper uses deep learning to redesign PETase, creating a highly active and stable enzyme for efficient PET degradation and industrial recycling.

Mechanism of broad-spectrum Cas9 inhibition by AcrIIA11

This study shows AcrIIA11 inhibits multiple Cas9 variants by trapping them on non-specific DNA, preventing target recognition and cleavage.

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

A novel method for robust estimation of ants' walking speed and curvature on convoluted trajectories derived from their gait pattern

This paper introduces a novel algorithm to estimate ants' walking speed and curvature on convoluted trajectories, showing it is more reliable than the conventional SLD method.

Evolutionary divergence of the Wsp signal transduction system in β- and γ-proteobacteria

This study shows the Wsp system is conserved across β- and γ-proteobacteria, with functional differences in Burkholderia cenocepacia compared to Pseudomonas species.

Droplet printing reveals the importance of micron-scale structure for bacterial ecology

The paper develops a droplet printing method to study bacterial ecology by manipulating spatial arrangements of E. coli strains and shows how micron-scale structure affects competition and coexistence.

Stretched-Exponential Modeling of Anomalous T1{rho} and T2 Relaxation in the Intervertebral Disc In Vivo

This study applies stretched-exponential modeling to T1{rho} and T2 relaxation data in intervertebral discs to better detect matrix composition changes associated with degeneration.

Naringenin as an antibacterial reagent controlling of biofilm formation and fatty acid metabolism in MRSA

This study identifies naringenin as an antibacterial agent that reduces biofilm formation and fatty acid secretion in MRSA and shows synergy with oxacillin.

A Holistic Analysis of the Intestinal Stem Cell Niche Network

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase Inhibition

This study identifies SAMHD1, dCK, and CDA as biomarkers for predicting sensitivity to PNP inhibitors in cancers, showing that PNP inhibition can target both hematological and solid tumors.

Gating Mechanism of β-Ketoacyl-ACP Synthases

The paper investigates the gating mechanism in β-ketoacyl-ACP synthases using structural and dynamic analyses to reveal how substrate discrimination occurs during catalytic reactions.

GIT2 is dispensable for normal learning and memory function due to a predominant brain GIT2 splice variant that evades GIT/PIX complexes.

The paper shows that GIT2 deficiency does not impair learning and memory due to a brain-specific splice variant that avoids forming GIT/PIX complexes.