Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity
Y. Zhang, L. Sui, Q. Du, L. Haataja, Y. Yin, R. Viola, S. Xu, C. U. Nielsson, R. L. Leibel, F. Barbetti, P. Arvan, D. Egli
This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.
bioRxiv · Sep 1, 2023Cell Biology