Q. Du

Phosphorylation-induced flexibility of proto-oncogenic Bcl3 regulates transcriptional activation by NF-κB p52 homodimer

This study shows phosphorylation at Ser366 enhances Bcl3's transcriptional activity by increasing C-terminal flexibility, enabling better DNA binding with p52:p52 complexes, and linking structural changes to cancer-related mutations.

Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity

This study investigates two INS mutations causing permanent neonatal diabetes, showing they impair beta cell function through misfolded proinsulin, ER stress, and dedifferentiation.

Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

The paper identifies PKR as a second dsRNA sensor aberrantly activated in Adar mutant mice and shows ADAR1 directly inhibits PKR through dsRNA-binding.

Gene Novelties in Amphioxus Illuminate the Early Evolution of Cephalochordates

This study identifies gene novelties in Amphioxus genomes that contribute to adaptive traits like immunity, glycolysis, and calcium regulation, offering insights into early deuterostome evolution.

The connection between Rap1 and Talin1 in CD4+ T Lymphocytes

This study investigates the role of Rap1-talin1 interactions and RIAM in integrin activation in CD4+ T cells, showing that RIAM can substitute for Rap1 binding in some contexts.

Single-nucleus RNA-seq resolves spatiotemporal developmental trajectories in the tomato shoot apex

This study uses snRNA-seq to create a high-resolution spatiotemporal gene expression atlas of tomato shoot apex cells, identifying distinct cell types and developmental regulators.

Maize EHD1 is Required for Kernel Development and Vegetative Growth through Regulating Auxin Homeostasis

This study identifies ZmEHD1's role in maize kernel development and growth by regulating auxin homeostasis through clathrin-mediated endocytosis.

Pharmacokinetics Modeling and Simulation of Voriconazole Dosing and Safety in Patients with Liver Cirrhosis

This study models voriconazole pharmacokinetics in cirrhotic patients and recommends reduced dosing for Child-Pugh C patients to improve safety.