Author

D. S. Auld

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Casalena· 2 shared A. Ali· 1 shared A. Deik· 1 shared A. Farsidjani· 1 shared A. G. Reidenbach· 1 shared A. Hilfinger· 1 shared A. I. Chan· 1 shared A. J. Campbell· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

D. Casalena

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SALLB not targeted by IMiDs is important for maintenance of liver cancer cells

K. A. L. Vu, S. Moein, K. Kumari, B. H. Liu, C. Gao, M. Liu, M.-Y. Dai, Z. Liu, F. Li, J. P. Tang, D. Maddalo, D. S. Auld, D. E. Casalena, X. Tian, M. A. Bassal, , L. Chai

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

bioRxiv · Jul 7, 2023 · PreprintCancer Biology

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

C. Tan, M. B. Ginzberg, R. Webster, S. Iyengar, J. Concannon, Y. Wang, D. S. Auld, J. L. Jenkins, H. Rost, A. Hilfinger, B. Derry, N. Patel, R. Kafri

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.

bioRxiv · Oct 14, 2020Cell Biology

Multimodal small-molecule screening for human prion protein binders

A. G. Reidenbach, M. F. Mesleh, D. Casalena, S. M. Vallabh, J. L. Dahlin, A. J. Leed, A. I. Chan, D. L. Usanov, J. B. Yehl, C. T. Lemke, A. J. Campbell, R. N. Shah, O. K. Shrestha, J. R. Sacher, V. L. Rangel, , E. V. Minikel

This study screens for small-molecule binders of the human prion protein using multiple methods but finds only a weak binder with no therapeutic potential.

bioRxiv · Jun 18, 2020Biochemistry