Dysfunction of Torr causes a Harlequin-type ichthyosis-like phenotype in Drosophila melanogaster
Y. Wang, M. Norum, K. Oehl, Y. Yang, R. Zuber, J. Yang, J.-P. Farine, N. Gehring, M. Floetenmeyer, J.-F. Ferveur, B. Moussian
This paper shows that the Drosophila Torr transporter is essential for cuticle barrier function, similar to the human ABCA12 gene's role in skin lipid barriers, causing desiccation and ichthyosis-like phenotypes when dysfunctional.
PLOS Genetics · Jan 13, 2020Peer-reviewedCell Biology