NeurosciencebioRxivPreprint
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres…·Li Gan
The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.