Evolutionary BiologybioRxivPreprint
Functional analysis of the Nematostella Wnt/β-catenin destruction complex provides insight into the evolution of a critical regulatory module in a major metazoan signal transduction pathway
Hongyan Sun, Brian M. Walters, Radim Zidek…·Athula H. Wikramanayake
The paper investigates the evolution of the Wnt/β-catenin destruction complex in Nematostella vectensis, showing it functions similarly to bilaterians despite lacking conserved domains, suggesting an ancestral low-affinity binding mechanism.
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