APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice
Mackenzie N. Kehmeier, Young Deanna Choi, Abigail E. Cullen, Benjamin Zimmerman, Thomas Leonhardt, Maddie Snyder, Tucker Cleveland, Naly Setthavongsack, Randy Woltjer, Martin M. Pike, Nabil J. Alkayed, Ashley E. Walker
This study investigates how APOE4 genotype and old age interact to affect cerebrovascular function, brain volume, and neuroinflammation in mice, finding that the interaction impacts these outcomes while age alone affects cognitive function and arterial stiffness.
bioRxiv · Jul 11, 2026 · PreprintNeuroscience