GeneticsGenome biologyPeer-reviewed
Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression
Pan Gao, Qing Lyu, Amr R. Ghanam…·Joseph M. Miano
This paper compares CRISPR-mediated HDR and PE2 systems in mice to show PE2's higher fidelity in editing a TFBS, leading to more effective tissue-specific gene inactivation.
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