BiophysicsbioRxivPreprint
Structural basis for activation of Dot1L methyltransferase on the nucleosome by histone H2BK120 ubiquitylation
Cathy J Anderson, Matthew R Baird, Allen Hsu…·Robert K McGinty
This study determines the cryo-EM structure of Dot1L bound to a ubiquitylated H2BK120 nucleosome, revealing how H2BK120 ubiquitylation activates Dot1L methylation of H3K79.
DOI 10.1101/503128