Automethylation of lysine methyltransferase SETDB1 on H3K9-like motifs regulates interactions with chromodomain proteins and controls its functions
Paola Cruz‐Tapias, Guillaume Velasco, Roberta Rapone, Laurence Del Maestro, Victor Cochard, Guillaume Chevreux, Véronique Joliot, Ekaterina Boyarchuk, Slimane Ait‐Si‐Ali
This study shows that SETDB1 automethylation on H3K9-like motifs is essential for its function in ESCs, affecting chromodomain interactions and H3K9me3 establishment.
bioRxiv · Oct 22, 2025 · PreprintMolecular Biology