Guillaume Chevreux

This study identifies MYC and MAX as critical for post-mitotic genome reactivation in pluripotent mouse embryonic stem cells, showing MAX's role in bookmarking and MYC recruitment.

This study identifies Cyclin B2 as a PKA substrate that phosphorylation at S271 represses Cdk1-Cyclin B activation, maintaining G2-arrest in vertebrate oocytes.

The paper uses low-input proteomics to compare proteome and phosphoproteome changes in wild-type and separase-deficient mouse oocytes, revealing specific alterations in chromosome-associated proteins.

This study shows that Greatwall kinase coordinates meiotic divisions by regulating PP2A-B55, which controls APC/C and Mos/MAPK pathways in Xenopus oocytes.

The paper identifies EMILIN1 as a TGFβ/SETDB1-regulated secreted biomarker in DMD, showing its role in fibrosis and myogenesis through proteomic analysis of patient-derived myotubes.

The paper identifies novel host factors interacting with TBEV RNA through an RNA-centric screen, revealing both proviral and antiviral proteins involved in viral replication and immune evasion.

This study identifies RNA-protein interactions between Hazara virus and Hyalomma tick proteins using ChIRP-MS, revealing mitochondrial RNA-binding proteins involved in metabolic pathways.

The paper identifies RanBP2-dependent annulate lamellae as a distinct pathway for nuclear pore assembly and nuclear expansion in somatic cells.

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

This study shows that SETDB1 automethylation on H3K9-like motifs is essential for its function in ESCs, affecting chromodomain interactions and H3K9me3 establishment.

This study identifies Reg1 mutations that confer resistance to 2-deoxyglucose in yeast by disrupting its role in Snf1 inhibition.

The paper shows PRC2 controls small RNA dynamics during DNA elimination in Paramecium by selectively degrading non-TE scnRNAs, independent of its histone methyltransferase activity.

This study investigates how PARP inhibitors affect DNA replication by causing replicative stress, altering replication timing, and disrupting replisome dynamics in human cells.

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

The paper identifies RNA-binding proteins and mRNP assembly perturbations that lead to R-loop accumulation and DNA damage, linking these processes to cancer and neurodegenerative diseases.

The paper identifies Gtsf1 as essential for selecting and degrading small RNAs in Paramecium, ensuring proper genome elimination during macronucleus development.

This study examines how mRNA localization to P-bodies changes during the cell cycle, revealing that mRNA dynamics in P-bodies are not solely linked to translation status but are regulated by RNA features and RBPs.

This paper creates a knockin mouse model with a K198R mutation in CK2 kinase, showing ASD-like behaviors and synaptic deficits, validating it as a model for Okur-Chung Neurodevelopmental Syndrome.

The paper compares phosphoproteome changes during mitotic exit and meiosis I completion in budding yeast, finding qualitative rather than quantitative phosphoregulation at meiosis I end.

The paper identifies N-terminal signatures in yeast proteins that influence mitochondrial import, showing hydrophobic residues at position 2 are critical and conserved across Saccharomycotina yeasts.