Florent Dingli

This study identifies L-CK1.2 interacting partners in Leishmania and host macrophages, revealing its dual role in parasite survival and host immune processes.

This paper develops a method to isolate cell-type-specific extracellular vesicles from infarcted mouse hearts and demonstrates their functional properties.

The paper identifies and characterizes two novel Plasmodium vivax merozoite proteins, PvMP45 and PvMP36, which bind reticulocyte receptors and are targets of protective antibodies, suggesting their potential as vaccine candidates.

This study shows that acetyl-CoA synthetase (ACAS) in Plasmodium falciparum is essential for nuclear histone acetylation, which regulates gene expression and the transcriptional cycle during the parasite's life cycle.

This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

This study identifies CD133 as a regulator of EV cargo and angiogenic function in BL-TNBC, showing its role in shaping EV composition and promoting tumor angiogenesis.

This study identifies how Leishmania donovani hijacks host ferritin to create an iron reservoir, protecting against oxidative stress and ferroptosis.

This paper identifies syntabulin as a determinant of chemosensitivity in high-grade serous ovarian cancer by linking mitochondrial metabolism and mitotic fidelity.

The paper identifies a shared persistence program in triple-negative breast cancer across treatments and patients, revealing key drivers and mechanisms of drug resistance.

The paper identifies CTNND2 as an SRGAP2 effector that regulates synaptic maturation and links human evolution to synaptic neoteny.

The paper identifies Ku-binding motifs in RAG2, XLF, PAXX, and MRI that mediate their interactions with Ku and support functional redundancy during V(D)J recombination.

This study shows that inhibiting LSD1 in macrophages reduces Leishmania parasite load and reverses infection-induced transcriptomic changes.

This study shows microglial TNFα regulates brain phosphorylation during sleep, affecting sleep need and duration through synaptic proteins.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

The paper shows that CSR-1 slicer activity and codon usage regulate 22G-RNA biogenesis in C. elegans germline mRNAs.

The paper shows that the Pif1 helicase is inhibited by the Mer3-MutLβ complex during meiotic recombination, limiting gene conversion tract length.

This study identifies astrocytes as key regulators of critical period closure in the mouse visual cortex through connexin 30-mediated inhibition of MMP9.

The paper shows that H3.3S31 phosphorylation is critical for development at gastrulation in Xenopus, regardless of the deposition pathway.

This study identifies CENP-T as essential for CenH3-independent kinetochore assembly in Lepidoptera, showing its role in recruiting the Mis12 complex and supporting mitotic progression.

This study uses SILAC-based proteomics to identify 86 differentially expressed proteins in murine macrophages infected with Leishmania donovani, revealing changes in host metabolism and lysosomal organization.

The paper identifies BAP1 as a general transcriptional co-activator through CRISPR/Cas9-generated isogenic cell lines and shows it functions independently of the Polycomb machinery.