Author

Rostam M. Razban

Primary ORCID profile (0000-0003-1055-4915 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Rostam M. RazbaniD4 papers · Stony Brook University

Biology Disciplines

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Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

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Eugene I. Shakhnovich· 1 shared Eugene Serebryany· 1 shared William M. Jacobs· 1 shared

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2019-2019 · peak 1/yr

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1 shared paperBiophysics

Eugene I. Shakhnovich

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintApr 29, 2019

Conformational catalysis of cataract-associated aggregation in a human eye lens crystallin occurs via interface stealing.

Eugene Serebryany, William M. Jacobs, Rostam M. Razban, Eugene I. Shakhnovich

This study reveals that wild-type HγD accelerates aggregation of the cataract-related W42Q variant through a mechanism called interface stealing, where intermolecular domain interactions outcompete native intramolecular stabilization.

DOI 10.1101/601708

humanprotein structure

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