Ruedi Aebersold

This study shows that PGC1a induces mitochondrial biogenesis and exercise-like adaptations in zebrafish, revealing conserved exercise responses and novel ETC organization.

The paper shows Nog1 uses ATPase and GTPase activities to coordinate removal of Arx1 and Mrt4 from pre-60S ribosomes, linking PET quality control with ribosomal stalk assembly.

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.

The paper investigates the dynamic structure of the MLL1 catalytic complex and shows it can be disrupted by pharmacological agents targeting specific interaction sites.

This study evaluates SWATH-MS across 11 labs, showing consistent detection and quantification of over 4,000 proteins with reproducible quantitative data.

This study maps the human Polycomb complexome using AP-MS, revealing new PcG complex interactions and distinct target gene binding by PR-DUB and PRC1 complexes.

This study uses proteomics to analyze metabolic syndrome in mice, showing differential molecular adaptations to dietary and genetic factors.

The paper identifies structural and kinetic mechanisms of COP9-Signalosome activation and Nedd8 deconjugation in cullin-RING ubiquitin ligase deneddylation.

This paper describes a protocol for automated SWATH MS data analysis, including manual and automated workflows for quality control and error rate control.