Molecular BiologyNature CommunicationsPeer-reviewed
Reliable repurposing of the antibody interactome inside the cell
Caitlin M. O’Shea, Rushba Shahzad, Kimia Aghasoleimani…·Gareth S. A. Wright
The paper develops methods to improve the solubility and stability of intrabodies by optimizing linker design, domain orientation, and charge properties, enabling effective intracellular targeting of cytoplasmic proteins.
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