Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus
Matthew G. Heffel, Jingtian Zhou, Yi Zhang…·Chongyuan Luo
The paper investigates epigenomic and 3D chromatin conformation changes in human frontal cortex and hippocampus development using sn-m3C-seq, finding distinct chromatin conformations in neurons and glial cells and linking risk variants to regulatory regions.