Author

Ryan T. Hietpas

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Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:yeast· 2 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Claudia Bank· 2 shared Jeffrey D. Jensen· 2 shared Daniel N.A. Bolon· 1 shared Sebastian Matuszewski· 1 shared

Activity by Year

2014-2016 · peak 1/yr

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4 top collaborators · 5 mutual co-author links

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2 shared papersEvolutionary Biology

Claudia Bank

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivSep 25, 2016

On the (un-)predictability of a large intragenic fitness landscape

Claudia Bank, Sebastian Matuszewski, Ryan T. Hietpas, Jeffrey D. Jensen

The paper analyzes a large multi-allelic fitness landscape in yeast Hsp90 to assess the predictability of evolution, finding local ruggedness and epistatic hotspots hinder extrapolation.

DOI 10.1073/pnas.1612676113

yeaststatistical model

𝕏 PostBluesky

Evolutionary BiologybioRxivOct 23, 2014

A systematic survey of an intragenic epistatic landscape

Claudia Bank, Ryan T. Hietpas, Jeffrey D. Jensen, Daniel N.A. Bolon

The paper analyzes intragenic epistatic effects in yeast Hsp90 mutants, finding common negative epistasis and rare positive epistasis, suggesting a concave fitness landscape and mutational robustness.

DOI 10.1093/molbev/msu301

yeastexperimental assay

𝕏 PostBluesky