Author

Ryutaro Hanyu

Brain Research Institute, Niigata University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Akihiro SugaiiD· 2 shared Aya Washida· 2 shared Genri ToyamaiD· 2 shared Osamu OnoderaiD· 2 shared Shingo KoideiD· 2 shared Takuma YamagishiiD· 2 shared Ekaterina Nadbitova· 1 shared Taisuke KatoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Akihiro SugaiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 12, 2025

Export-biased, 3'UTR-preserving TDP-43 model links nuclear loss to cytoplasmic aggregation in ALS/FTLD

Genri Toyama, Shingo Koide, Takuma Yamagishi…·Akihiro Sugai

This study shows that export-biased TDP-43 with intact 3' UTR leads to cytoplasmic aggregation and splicing defects, even when exogenous levels match endogenous, suggesting loss of nuclear function.

DOI 10.1101/2025.11.12.687969

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 22, 2024

ASO-enhancement of TARDBP exitron splicing mitigates TDP-43 proteinopathies

Takuma Yamagishi, Shingo Koide, Genri Toyama…·Akihiro Sugai

This paper shows that enhancing TARDBP exitron splicing reduces TDP-43 aggregation and neurodegeneration in disease models using ASOs.

3 citations

mouseexperimental assay

𝕏 PostBluesky