Cell BiologybioRxiv
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
N. Volkmar, S. A. Menzies, D. J. van den Boomen…·P. J. Lehner
This study identifies RNF145 as a sterol-responsive E3 ubiquitin ligase that, along with gp78 and Hrd1, mediates HMGCR degradation in response to sterol levels.
DOI 10.7554/elife.40009