S. A. Vanapalli

Inertial Focusing of Particles and Cells in the Microfluidic Labyrinth Device: Role of Sharp Turns

This study investigates inertial focusing of particles and cells in a microfluidic labyrinth device with sharp turns, finding that turns improve cell separation but are less effective for rigid particles.

Staining-Free, In-Flow Enumeration of Tumor Cells in Blood Using Digital Holographic Microscopy and Deep Learning

This paper demonstrates a staining-free method for detecting tumor cells in blood using digital holographic microscopy and deep learning, achieving high accuracy and low false positive rates.

Investigating the correlation of muscle function tests and sarcomere organization in C. elegans

This study investigates the relationship between muscle function and sarcomere organization in C. elegans using two assays, finding that mutants with sarcomere defects show reduced muscle strength and that combined assays improve phenotyping.

Multi-environment phenotyping of C. elegans for robust evaluation of physical performance

This study introduces a multi-environment phenotyping approach to assess physical performance in C. elegans and evaluates drug interventions in a muscular dystrophy model.

A Region of UNC-89 (obscurin) Lying Between Two Protein Kinase Domains is a Highly Elastic Spring Required for Proper Sarcomere Assembly

This paper identifies a highly elastic interkinase region in UNC-89 essential for sarcomere assembly, showing that its deletion causes sarcomere disorganization and locomotion defects in C. elegans.

NemaLife: A structured microfluidic culture device optimized for aging studies in crawling C. elegans

The paper introduces NemaLife, a microfluidic device for aging studies in C. elegans that allows crawling, prevents progeny contamination, and enables reagent addition, validated with longevity and healthspan analyses.