M. Rahman

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

Beta-cell adaptation to metabolic stresses requires prolactin receptor signaling

This study shows that prolactin receptor signaling protects beta-cells from metabolic stress by maintaining incretin receptor expression and insulin secretion.

mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

TFAM-dependent mitochondrial integrity in regulatory T cells preserves immune landscape and restrains inflammaging

This study identifies TFAM-dependent mitochondrial integrity in Tregs as critical for preserving immune homeostasis and preventing inflammaging.

Exploring Genomic Conservation in Actinobacteriophages with Small Genomes

This study examines genomic conservation in small actinobacteriophages, finding significant gene content similarity and conserved phams across different clusters and hosts.

Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

An Antioxidant Polysaccharide from Ganoderma lucidum Induces Apoptotic Activity in Breast Cancer Cell Line

This study shows that Ganoderma lucidum polysaccharide induces apoptosis in MCF-7 breast cancer cells by modulating Bax, Caspase-9, and BcL-2 expression.

Nipah virus detection at bat roosts following spillover events in Bangladesh, 2012-2019

The paper investigates Nipah virus shedding in bat roosts near human cases in Bangladesh, finding that viral RNA can be detected up to 52 days post-exposure, supporting targeted sampling for better viral ecology understanding.

Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS2-N501YMA30 strain of SARS-CoV-2

Development of a novel glycoengineering platform for the rapid production of conjugate vaccines.

This paper develops a novel glycoengineering platform, MAGIC, which increases glycoconjugate yield and enables vaccine development in genetically intractable bacteria.

Senotherapeutic peptide reduces skin biological age and improves skin health markers

This study identifies a senotherapeutic peptide that reduces skin biological age and improves skin health markers, outperforming Retinol and extending lifespan in C. elegans.

Effect of sanitation improvements on soil-transmitted helminth eggs in courtyard soil from rural Bangladesh: Evidence from a cluster-randomized controlled trial

This study evaluates a sanitation program's effect on reducing soil-transmitted helminth eggs in courtyard soil, finding no significant impact despite high latrine uptake.

Virome-wide serological profiling reveals association of herpesviruses with obesity

This study uses ViScan to find HSV-1 and Rhinovirus A associations with obesity in Qatari adults, but not children.

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

Distinct antibody repertoires against endemic human coronaviruses in children and adults

The paper analyzes antibody repertoires against endemic human coronaviruses in children and adults, finding distinct epitope targets and cross-reactivity patterns.

Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

Impact of the radiated brain microenvironment on a panel of human patient-derived xenografts.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

A molecular map of lymph node blood vascular endothelium at single cell resolution

The paper maps the molecular diversity of lymph node blood vascular endothelial cells at single-cell resolution, identifying novel subsets and their roles in immune cell recruitment and vascular homeostasis.

Quantitative assessment of fecal contamination in multiple environmental sample types in urban communities in Dhaka, Bangladesh using SaniPath microbial approach

The paper assesses fecal contamination in urban Dhaka using E. coli MPN measurements across different environmental samples and finds higher contamination in low-income areas compared to high-income and transient neighborhoods.

NemaLife: A structured microfluidic culture device optimized for aging studies in crawling C. elegans

The paper introduces NemaLife, a microfluidic device for aging studies in C. elegans that allows crawling, prevents progeny contamination, and enables reagent addition, validated with longevity and healthspan analyses.

Characterization of Streptococcus pneumoniae phage-like element SpnCI reveals an enhanced virulent phenotype in the acute invertebrate infection model Galleria mellonella

This study shows that the phage-like element SpnCI enhances virulence in Streptococcus pneumoniae by altering transcription, increasing UV sensitivity, and affecting infection dynamics in Galleria mellonella.

Elucidating Variants in Systemic JIA from Analysis of Illumina & Ion Torrent Exome Data

The paper identifies genetic variants in systemic JIA using exome data from Ion Torrent and Illumina, finding mutations in the Fc epsilon RI pathway and variants in HLA regions.