Cell BiologybioRxiv
Hypertrophied human adipocyte spheroids as in vitro model of weight gain and adipose tissue dysfunction
A. Ioannidou, S. Alatar, M. Ahlander…·C. E. Hagberg
This study develops a 3D culture protocol for human adipocytes that mimics in vivo adipogenesis and induces adipocyte hypertrophy, leading to dysfunction features like altered adipokine secretion and impaired lipolysis.
DOI 10.1113/jp281445