Polymeric nanoparticles delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne Muscular Dystrophy
I. Andreana, A. Kneppers, S. Ben Larbi, F. Tifni, A. Fessard, J. Sidi-Boumedine, D. Kryza, B. Stella, C. Bordes, S. Arpicco, Y. Chevalier, B. Chazaud, R. Mounier, G. Lollo, G. Juban
This paper shows that delivering AMPK activator 991 via polymeric nanoparticles reduces toxicity and improves muscle homeostasis in a DMD mouse model.
bioRxiv · Jan 16, 2024Pathology