B. Chazaud

Polymeric nanoparticles delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne Muscular Dystrophy

This paper shows that delivering AMPK activator 991 via polymeric nanoparticles reduces toxicity and improves muscle homeostasis in a DMD mouse model.

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD

This study shows that altered muscle niche in D2-mdx mice leads to poor myogenesis and increased degeneration, but reversing this improves regeneration in adult mice.

Individualized isometric neuromuscular electrical stimulation training promotes myonuclear accretion in mouse skeletal muscle

This study shows that individualized NMES training induces myonuclear accretion in mouse skeletal muscle without causing damage or hypertrophy.

Myofiber / pro-inflammatory macrophage interplay controls muscle damage in mdx mice

This study shows that dystrophic myofibers promote pro-inflammatory macrophage polarization, leading to muscle damage, and that H2S donors can reduce inflammation and fibrosis in mdx mice.

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation

This study shows that AMPKα1 is required for glucocorticoid receptor-mediated anti-inflammatory macrophage activation, linking metabolism to inflammation resolution.