G. Juban

Polymeric nanoparticles delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne Muscular Dystrophy

This paper shows that delivering AMPK activator 991 via polymeric nanoparticles reduces toxicity and improves muscle homeostasis in a DMD mouse model.

Alterations of the TGFb-sequestration complex member ADAMTSL1 levels are associated with muscular defects and rhabdomyosarcoma aggressiveness

This study shows ADAMTSL1 is involved in skeletal muscle regeneration and acts as a prognostic factor in aggressive rhabdomyosarcoma, correlating with a neural-like phenotype.

Myofiber / pro-inflammatory macrophage interplay controls muscle damage in mdx mice

This study shows that dystrophic myofibers promote pro-inflammatory macrophage polarization, leading to muscle damage, and that H2S donors can reduce inflammation and fibrosis in mdx mice.

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation

This study shows that AMPKα1 is required for glucocorticoid receptor-mediated anti-inflammatory macrophage activation, linking metabolism to inflammation resolution.

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

This study identifies stage-specific differentiation delays caused by GATA1s in megakaryocytes, leading to increased immature cells and altered gene expression.

Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation

This study identifies Annexin A1 as a driver of macrophage polarization towards a resolving phenotype via AMPK activation, enhancing muscle regeneration after injury.