Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels
A. Accardi, L. Leisle, Y. Xu, E. Fortea, J. D. Galpin, M. Vien, C. A. Ahern, S. Berneche
This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.
bioRxiv · Sep 5, 2019Biochemistry