Author

A. Accardi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Organism:fungi (other)· 1 Organism:human· 1

Frequent Co-Authors

C. A. Ahern· 2 shared E. Fortea· 2 shared J. D. Galpin· 2 shared L. Leisle· 2 shared M. E. Falzone· 2 shared A. C. W. Pike· 1 shared A. Chu· 1 shared A. Di Lorenzo· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

C. A. Ahern

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5 papers

Recent·Most cited

Structural basis of closed groove scrambling by a TMEM16 protein

Z. Feng, O. E. Alvarenga, A. Accardi

This study uses cryoEM to visualize lipid interactions at the closed groove of Ca2+-bound nhTMEM16 and identifies structural changes involved in groove opening and lipid scrambling.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Backbone amides are key determinants of Cl- selectivity in CLC ion channels

L. Leisle, K. Lam, S. Dehghanighahnaviyeh, E. Fortea, J. D. Galpin, C. A. Ahern, E. Tajkhorshid, A. Accardi

The paper shows that backbone amides in CLC channels are critical for Cl- selectivity, as replacing them with ester groups reduces ion discrimination.

bioRxiv · Jul 1, 2022 · PreprintBiophysics

Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels

A. Accardi, L. Leisle, Y. Xu, E. Fortea, J. D. Galpin, M. Vien, C. A. Ahern, S. Berneche

This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.

bioRxiv · Sep 5, 2019Biochemistry

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

S. R. Bushell, A. C. W. Pike, M. E. Falzone, N. J. G. Rorsman, C. M. Ta, R. A. Corey, T. D. Newport, C. A. Shintre, A. Tessitore, A. Chu, Q. Wang, L. Shrestha, S. Mukhopadhyay, J. D. Love, N. A. Burgess-Brown, , E. P. Carpenter

This study identifies TMEM16K as an ER-resident calcium-regulated lipid scramblase and elucidates its structural basis for lipid scrambling and inactivation.

bioRxiv · Dec 12, 2018Biochemistry

Cryo-EM structures reveal bilayer remodeling during Ca2+ activation of a TMEM16 scramblase

M. E. Falzone, J. Rheinberger, B.-C. Lee, T. Peyear, L. Sasset, A. Raczkowski, E. Eng, A. Di Lorenzo, O. S. Andersen, C. M. Nimigean, A. Accardi

The paper presents cryo-EM structures of a fungal TMEM16 scramblase showing Ca2+-induced conformational changes and membrane reorganization.

bioRxiv · Nov 5, 2018Biochemistry