Author

E. Fortea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

Frequent Co-Authors

A. Accardi· 2 shared C. A. Ahern· 2 shared J. D. Galpin· 2 shared L. Leisle· 2 shared B. Qiu· 1 shared D. Matthies· 1 shared E. Tajkhorshid· 1 shared K. Lam· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

A. Accardi

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Author profile →

3 papers

Recent·Most cited

Backbone amides are key determinants of Cl- selectivity in CLC ion channels

L. Leisle, K. Lam, S. Dehghanighahnaviyeh, E. Fortea, J. D. Galpin, C. A. Ahern, E. Tajkhorshid, A. Accardi

The paper shows that backbone amides in CLC channels are critical for Cl- selectivity, as replacing them with ester groups reduces ion discrimination.

bioRxiv · Jul 1, 2022 · PreprintBiophysics

Transport mechanism of the neuronal excitatory amino acid transporter

B. Qiu, D. Matthies, E. Fortea, Z. Yu, O. Boudker

The paper reports Cryo-EM structures of hEAAT3 in different functional states, revealing an elevator mechanism for glutamate transport and conserved sodium-substrate coupling.

bioRxiv · Jun 1, 2020 · PreprintBiophysics

Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels

A. Accardi, L. Leisle, Y. Xu, E. Fortea, J. D. Galpin, M. Vien, C. A. Ahern, S. Berneche

This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.

bioRxiv · Sep 5, 2019Biochemistry