Direct monitoring of cAMP at the cardiac ryanodine receptor using a novel targeted fluorescence biosensor mouse
F. Berisha, K. Goetz, J. Wegener, C. Jungen, U. Pape, A. Kraft, S. Warnke, D. Lindner, D. Westermann, S. Blankenberg, C. Meyer, G. Hasenfuss, S. Lehnart, V. Nikolaev
The paper develops a targeted fluorescence biosensor in transgenic mice to monitor cAMP levels near RyR2 in cardiomyocytes, revealing altered cAMP dynamics in cardiac hypertrophy.
bioRxiv · Apr 30, 2019 · PreprintCell Biology