D. Lindner

Cell-autonomous GP130 activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment

This study shows that activating GP130 in prostate epithelial cells suppresses tumor growth through senescence and immune activation, suggesting a new therapeutic approach.

JUN mediates senescence and immune cell recruitment to prevent prostate cancer progression

This study shows JUN suppresses prostate cancer progression by inducing senescence and immune cell recruitment, with JUN depletion accelerating tumor growth.

Turnover of PPP1R15A mRNA encoding GADD34 controls the molecular memory of the cellular integrated stress response

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.

Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function

Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries

This study uses human cardiac organoids to model COVID-19-induced cardiac injuries by simulating cytokine storm effects and evaluates potential therapeutic interventions.

CDK1 couples proliferation with protein synthesis

This study identifies CDK1 as a regulator of translation that couples cell proliferation with protein synthesis by modulating 5TOP mRNA translation through LARP1.

Direct monitoring of cAMP at the cardiac ryanodine receptor using a novel targeted fluorescence biosensor mouse

The paper develops a targeted fluorescence biosensor in transgenic mice to monitor cAMP levels near RyR2 in cardiomyocytes, revealing altered cAMP dynamics in cardiac hypertrophy.