Non-preferential, but detrimental accumulation of macrophages with clonal hematopoiesis-driver mutations in cardiovascular tissues
T.-s. Dederichs, A. Yerdenova, H. Horstmann, T. Vico, S. Nuebling, R. Peyronnet, C. von zur Muehlen, T. Heidt, D. Wolf, D. Westermann, I. Hilgendorf
The paper quantifies CHIP mutated macrophages in cardiovascular tissues and finds they do not preferentially accumulate but exhibit a more disease-prone phenotype.
bioRxiv · Sep 11, 2023 · PreprintImmunology