Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening
O. Maller, A. P. Drain, A. S. Barrett, S. Borgquist, B. Ruffell, P. T. Thanh, T. Gruosso, H. Kuasne, J. N. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, A. Chauhan, J. Gruenberg, A. Nasir, , V. M. Weaver
This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.
bioRxiv · Feb 13, 2020Cancer Biology