Author

B. Ruffell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. El-Kenawi· 2 shared J. Dhillon· 2 shared A. Anderson· 1 shared A. Berglund· 1 shared A. C. Nelson· 1 shared A. Chauhan· 1 shared A. Ibrahim-Hashim· 1 shared A. Keske· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. El-Kenawi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

O. Maller, A. P. Drain, A. S. Barrett, S. Borgquist, B. Ruffell, P. T. Thanh, T. Gruosso, H. Kuasne, J. N. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, A. Chauhan, J. Gruenberg, A. Nasir, , V. M. Weaver

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

bioRxiv · Feb 13, 2020Cancer Biology

Acidity promotes tumor progression by altering macrophage phenotype in prostate cancer

A. El-Kenawi, C. Gatenbee, M. Robertson-Tessi, R. Bravo, J. Dhillon, Y. Balagurunathan, A. Berglund, N. Visvakarma, A. Ibrahim-Hashim, J. Choi, K. Luddy, R. Gatenby, S. P. Thomas, A. Anderson, B. Ruffell, R. Gillies

This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.

bioRxiv · Nov 26, 2018Immunology