Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
K. Kersten, R. You, S. Liang, K. Tharp, J. Pollack, V. M. Weaver, M. F. Krummel, M. B. Headley
This study shows that uptake of tumor-derived microparticles by macrophages in the early metastatic lung leads to metabolic reprogramming and altered function.
bioRxiv · Nov 15, 2022Immunology
G. A. Timblin, K. M. Tharp, J. t. Hoeve, D. S. Kantner, I. Baydemir, E. A. Noel, C. Khantwal, P. K. Singh, J. N. Farahzad, J. Dominguez-Andres, R. E. Vance, N. W. Snyder, V. M. Weaver
This study shows that exogenous CoA enhances TLR-driven proinflammatory and antimicrobial responses in macrophages by promoting oxidative metabolism and histone acetylation.
bioRxiv · Aug 30, 2022 · PreprintImmunology
K. Pedram, D. J. Shon, G. S. Tender, N. R. Mantuano, J. J. Northey, K. J. Metcalf, S. P. Wisnovsky, N. M. Riley, G. C. Forcina, S. A. Malaker, A. Kuo, B. M. George, C. L. Miller, K. M. Casey, J. G. Vilches-Moure, , C. R. Bertozzi
This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.
bioRxiv · May 20, 2022Biochemistry
J. J. Northey, Y. Yui, M.-K. Hayward, C. Stashko, F. Kai, J. K. Mouw, D. Thakar, J. N. Lakins, A. J. Ironside, S. Samson, R. A. Mukhtar, E. S. Hwang, V. M. Weaver
The paper shows that stiff extracellular matrix and integrin mechanosignaling increase mammary stem-progenitor cells, promoting breast cancer risk and progression through RANK signaling.
bioRxiv · Apr 19, 2022 · PreprintCancer Biology
F. Kai, G. Ou, R. W. Tourdot, C. Stashko, G. Gaietta, M. F. Swift, N. Volkmann, A. F. Long, Y. Han, H. H. Huang, J. J. Northey, A. M. Leidal, V. Viasnoff, D. M. Bryant, W. Guo, , V. M. Weaver
The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.
bioRxiv · Jul 14, 2021 · PreprintCell Biology
K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver
The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.
bioRxiv · Mar 6, 2020Cell Biology
O. Maller, A. P. Drain, A. S. Barrett, S. Borgquist, B. Ruffell, P. T. Thanh, T. Gruosso, H. Kuasne, J. N. Lakins, I. Acerbi, J. M. Barnes, T. Nemkov, A. Chauhan, J. Gruenberg, A. Nasir, , V. M. Weaver
This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.
bioRxiv · Feb 13, 2020Cancer Biology
A. R. G. Libby, D. A. Joy, P.-L. So, M. A. Mandegar, J. M. Muncie, V. M. Weaver, B. R. Conklin, T. C. McDevitt
This study uses CRISPR interference to create spatiotemporal patterns in hiPSC colonies, revealing how gene knockdowns affect multicellular organization and symmetry breaking during development.
bioRxiv · Jan 24, 2018Bioengineering
E. C. Woods, J. M. Barnes, M. W. Pickup, K. Pedram, F. Kai, M. J. Hollander, V. M. Weaver, C. R. Bertozzi
This study shows that a bulky glycocalyx promotes metastasis by enabling G1 cell cycle progression through integrin adhesion and signaling.
bioRxiv · Jun 28, 2017Cancer Biology