YAP restricts renal inflammation and mitigates kidney damage in nephronothisis related kidney disease.
G. Ferri, V. Goffette, E. Poree, S. Braeg, S. Carvalho, M. Quatredeniers, E. W. Kuehn, S. Saunier, A. Viau
This study investigates the role of YAP in NPH-like kidney disease and finds that YAP inhibition is not therapeutic, suggesting LKB1 and YAP are parallel regulators of a harmful pathway.
bioRxiv · Jan 17, 2022 · PreprintPathology