Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits
J.-C. Park, A. Luebbers, M. Dao, A. Semeano, M. P. Papakonstantinou, S. Broselid, H. Yano, K. Martemyanov, M. Garcia-Marcos
The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.
bioRxiv · Mar 3, 2023Biochemistry