M. Dao

Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics

This study uses computational models to show that deformable interendothelial slits in the spleen better predict RBC filtration compared to rigid models, improving understanding of splenic hemodynamics and filtration mechanisms.

Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

This study compares SEC-DGUC and DGUC-SEC protocols for isolating high-purity sEVs from small plasma volumes, finding SEC-DGUC yields higher protein and RNA content.

A combined computational and experimental investigation of the filtration function of splenic macrophages in sickle cell disease

This study combines computational modeling and experiments to show that hypoxia and RBC aggregation enhance macrophage retention of sickle RBCs, contributing to splenic congestion in SCD.

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

An In Vivo Method for Diversifying the Functions of Therapeutic Antibodies

This paper develops a method to diversify therapeutic antibodies by mimicking natural B cell processes in mice, resulting in new antibodies with altered functions.

Conditional Antibody Expression to Avoid Central B Cell Deletion in a Humanized HIV-1 Vaccine Mouse Models

This paper develops a conditional expression strategy to enable mature B cell expression of bnAb precursors in transgenic mice, overcoming developmental blocks caused by bnAb properties.