Author

A. Semeano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

H. Yano· 3 shared A. Bonifazi· 1 shared A. H. Newman· 1 shared A. Inoue· 1 shared A. Luebbers· 1 shared A. M. Nguyen· 1 shared D. E. Nichols· 1 shared F. O. Battiti· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

H. Yano

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Linkers in bitopic agonists shape bias profile among transducers for the dopamine D2 and D3 receptors

A. Semeano, R. Garland, A. Bonifazi, K. H. Lee, J. Famiglietti, W. Zhang, Y. J. Jo, F. O. Battiti, L. Shi, A. H. Newman, H. Yano

The paper analyzes bitopic ligands for dopamine D2 and D3 receptors, showing that linker structure and stereochemistry significantly influence transducer bias profiles.

bioRxiv · Jan 7, 2024Pharmacology & Toxicology

Characterization of Gαs and Gαolf activation by catechol and non-catechol dopamine D1 receptor agonists

A. M. Nguyen, A. Semeano, V. Quach, A. Inoue, D. E. Nichols, H. Yano

This study evaluates how different dopamine D1 receptor agonists activate Gαs and Gαolf, revealing region-specific pharmacological profiles with implications for targeted drug development.

bioRxiv · Oct 3, 2023 · PreprintPharmacology & Toxicology

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits

J.-C. Park, A. Luebbers, M. Dao, A. Semeano, M. P. Papakonstantinou, S. Broselid, H. Yano, K. Martemyanov, M. Garcia-Marcos

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

bioRxiv · Mar 3, 2023Biochemistry