M. Garcia-Marcos

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

The paper develops a biosensor platform to measure GPCR activity in various contexts, revealing insights into coupling selectivity, pharmacogenomics, and signaling bias.

Synaptic plasticity via receptor tyrosine kinase / G protein-coupled receptor crosstalk

The paper identifies a novel form of hippocampal synaptic plasticity mediated by TrkB and mGluR5 crosstalk in response to BDNF.

Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP

This study identifies the molecular mechanism by which GINIP modulates GPCR signaling through conformational changes in its PHD domain, essential for Gi subunit binding and regulation of G-protein signaling.

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

This study introduces IGGi-11, a small-molecule inhibitor that blocks non-canonical G-protein signaling by disrupting GIV/Girdin interaction, inhibiting cancer metastasis without affecting canonical GPCR signaling.

Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein

The paper introduces LOV2GIVe, a modular protein that optogenetically activates Gi proteins using blue light, offering a new tool for precise G-protein manipulation.

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.