Author

A. Luebbers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Garcia-Marcos· 5 shared J.-C. Park· 3 shared J. Zhao· 2 shared M. Maziarz· 2 shared A. Beeler· 1 shared A. I. de Opakua· 1 shared A. Marivin· 1 shared A. Semeano· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersBiochemistry

M. Garcia-Marcos

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Author profile →

5 papers

Recent·Most cited

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

R. Janicot, M. Maziarz, J.-C. Park, A. Luebbers, E. Green, J. Zhao, C. E. Philibert, H. Zhang, M. D. Layne, J. C. Wu, M. Garcia-Marcos

The paper develops a biosensor platform to measure GPCR activity in various contexts, revealing insights into coupling selectivity, pharmacogenomics, and signaling bias.

Cell · Mar 1, 2024Peer-reviewedBiochemistry

Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP

A. Luebbers, M. Zhou, S. Eyles, M. Garcia-Marcos

This study identifies the molecular mechanism by which GINIP modulates GPCR signaling through conformational changes in its PHD domain, essential for Gi subunit binding and regulation of G-protein signaling.

bioRxiv · Apr 20, 2023Biochemistry

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits

J.-C. Park, A. Luebbers, M. Dao, A. Semeano, M. P. Papakonstantinou, S. Broselid, H. Yano, K. Martemyanov, M. Garcia-Marcos

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

bioRxiv · Mar 3, 2023Biochemistry

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

J. Zhao, V. DiGiacomo, M. Ferreras-Gutierrez, S. Dastjerdi, A. I. de Opakua, J.-C. Park, A. Luebbers, Q. Chen, A. Beeler, F. J. Blanco, M. Garcia-Marcos

This study introduces IGGi-11, a small-molecule inhibitor that blocks non-canonical G-protein signaling by disrupting GIV/Girdin interaction, inhibiting cancer metastasis without affecting canonical GPCR signaling.

bioRxiv · Feb 18, 2023Biochemistry

Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein

M. Garcia-Marcos, K. Parag-Sharma, A. Marivin, M. Maziarz, A. Luebbers, L. T. Nguyen

The paper introduces LOV2GIVe, a modular protein that optogenetically activates Gi proteins using blue light, offering a new tool for precise G-protein manipulation.

bioRxiv · Aug 17, 2020Biochemistry