Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.
S. Dzanibe, A. J. Wilk, S. Canny, T. Ranganath, B. Alinde, F. Rubelt, H. Huang, M. Davis, S. P. Holmes, H. B. Jaspan, C. A. Blish, C. M. Gray
This study shows that HIV/ARV-exposed uninfected infants have reduced T cell receptor diversity and altered immune development, increasing infection risk.
bioRxiv · May 19, 2023 · PreprintImmunology