M. Davis

In a nutshell: pistachio genome and kernel development

This study generates a chromosome-scale pistachio genome and analyzes kernel development stages to understand molecular pathways affecting nutritional quality.

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

This study identifies elevated oxidative stress in both ME/CFS and Long COVID patients through blood cell analysis, suggesting shared molecular mechanisms and potential therapeutic targets.

Flavonols improve thermotolerance in tomato pollen during germination and tube elongation by maintaining ROS homeostasis

Flavonols reduce heat-induced ROS and modulate transcriptome changes to improve thermotolerance in tomato pollen.

DeltaAI: Semi-Autonomous Tissue Grossing Measurements and Recommendations using Neural Radiance Fields for Rapid, Complete Intraoperative Histological Assessment of Tumor Margins

DeltaAI uses Neural Radiance Fields to create 3D tissue models for faster and more accurate intraoperative tumor margin assessment in Mohs Micrographic Surgery.

Potential to Enhance Large Scale Molecular Assessments of Skin Photoaging through Virtual Inference of Spatial Transcriptomics from Routine Staining

This paper develops machine learning models to infer spatial transcriptomics data from H&E-stained skin slides, improving the assessment of photoaging and its therapeutic implications.

Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.

This study shows that HIV/ARV-exposed uninfected infants have reduced T cell receptor diversity and altered immune development, increasing infection risk.

Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

The structure of the enigmatic ripple phase in saturated bilayers resolved: Machine learning reveals four lipid populations

The paper uses machine learning to analyze MD simulations of DPPC bilayers and identifies four distinct lipid populations in the ripple phase.

Problems using ordinal traits with continuous measures of functional diversity

The paper evaluates how ordinal trait data affect continuous functional diversity indices, finding that small methodological choices can drastically alter results.

Monitoring the microbiome for food safety and quality using deep shotgun sequencing

The paper uses deep shotgun sequencing to analyze food microbiomes, identifying microbial genera and observing shifts related to ingredient composition, but finds limited correlation between RNA sequencing and Salmonella growth.

Functionally unique, specialised, and endangered (FUSE) species: towards integrated metrics for the conservation prioritisation toolbox

The paper develops the FUSE index to identify species that are both functionally unique and endangered, enhancing conservation prioritisation by integrating functional diversity with extinction risk.

Compensatory guaiacyl lignin biosynthesis at the expense of syringyl lignin in 4CL1-knockout poplar

Knockout of 4CL1 in Populus reveals a 4CL5-dependent compensatory pathway for lignification with links to thiol redox balance and sulfur assimilation.

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

CD38 contributes to human natural killer cell responses through a role in immune synapse formation

This study identifies CD38 as a key receptor in human NK cells that facilitates immune synapse formation, enhancing antiviral and antitumor responses.

Microbial Food Safety in the Maryland Direct-to-Consumer Poultry Supply Chain

This study compares microbial safety in Maryland direct-to-consumer poultry products to conventional supply chains, finding lower rates of antimicrobial-resistant pathogens.

Tetraploidy in rodent cardiac stem cells confers enhanced biological properties

The paper compares ploidy in cardiac interstitial cells between rodents and large mammals, finding species-specific differences in tetraploidy and its functional implications.

Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity

This study shows Activin-A inhibits NK cell function, promotes transdifferentiation into ILC1-like cells, and suppresses anti-tumor immunity, with therapeutic blockade improving outcomes.