A. J. Wilk

This study identifies NK cell-monocyte interactions as a driver of NK cell activation and dysfunction in severe COVID-19 through computational and in vitro experiments.

This study shows that HIV/ARV-exposed uninfected infants have reduced T cell receptor diversity and altered immune development, increasing infection risk.

This study identifies pro-inflammatory feedback loops in immune responses to pathogenic lentivirus infection, showing that highly pathogenic variants induce delayed, sustained, and amplifying inflammatory circuits.

This paper introduces Scriabin, a framework for analyzing cell-cell communication at single-cell resolution, validating its findings through multiple experimental approaches and demonstrating its application in uncovering communication pathways in health and disease.

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

The paper responds to criticisms of a previous study on transdifferentiation of plasmablasts to neutrophils in severe COVID-19 using single-cell transcriptomic data.

This study introduces CARTs, a non-viral transfection method for primary human NK cells, enabling efficient mRNA delivery without activation, preserving phenotype and function, and demonstrating therapeutic potential.