Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics
I. Tzani, N. Herrmann, S. Carillo, C. A. Spargo, R. Hagan, N. Barron, J. Bones, W. S. Dillmore, C. Clarke
The paper uses single-cell RNA-seq to analyze production instability in a clonally-derived CHO cell line, identifying transcriptional changes and oxidative stress responses during mAb production decline.
bioRxiv · Nov 4, 2020Cell Biology