Author

J. Bones

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Clarke· 2 shared F. Guapo· 2 shared I. Anderson· 2 shared I. Tzani· 2 shared L. Strasser· 2 shared N. Barron· 2 shared R. Hagan· 2 shared A. Costello· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

C. Clarke

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4 papers

Recent·Most cited

Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs)

F. Guapo, L. Strasser, S. Millan-Martin, I. Anderson, J. Bones

The paper describes a fast method to digest AAV5 capsid proteins for LC-MS peptide mapping and PTM analysis, achieving 100% sequence coverage.

bioRxiv · Aug 11, 2021Biochemistry

A native mass spectrometry-based assay for rapid assessment of the empty/full capsid ratio in AAV gene therapy products

L. Strasser, T. E. Morgan, F. Guapo, F. Fuessl, D. Forsey, I. Anderson, J. Bones

The paper introduces a native mass spectrometry assay to rapidly assess the empty/full capsid ratio in AAV gene therapy products, showing good correlation with traditional methods.

bioRxiv · Jul 6, 2021Biochemistry

Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics

I. Tzani, N. Herrmann, S. Carillo, C. A. Spargo, R. Hagan, N. Barron, J. Bones, W. S. Dillmore, C. Clarke

The paper uses single-cell RNA-seq to analyze production instability in a clonally-derived CHO cell line, identifying transcriptional changes and oxidative stress responses during mAb production decline.

bioRxiv · Nov 4, 2020Cell Biology

Sub physiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

I. Tzani, C. Monger, K. Motheramgari, C. Gallagher, R. Hagan, P. Kelly, A. Costello, J. Meiller, P. Floris, L. Zhang, M. Clynes, J. Bones, N. Barron, C. Clarke

This study shows that reducing temperature induces widespread alternative splicing in CHO cells, with many events occurring in genes not detected by standard expression analysis.

bioRxiv · Dec 3, 2019Cell Biology