Cell BiologybioRxiv
Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics
I. Tzani, N. Herrmann, S. Carillo…·C. Clarke
The paper uses single-cell RNA-seq to analyze production instability in a clonally-derived CHO cell line, identifying transcriptional changes and oxidative stress responses during mAb production decline.