BiochemistrybioRxiv
Cryo-EM reveals disrupted human p97 allosteric activation by disease mutations and inhibitor binding
B. Caffrey, X. Zhu, A. Berezuk…·S. Subramaniam
This study uses cryo-EM to analyze disease mutations and inhibitor binding in p97, revealing how these affect allosteric activation and provide insights into their mechanistic link to dysfunction.