S. Subramaniam

The Arabidopsis Information Resource in 2024

The paper updates the Arabidopsis Information Resource, detailing its curation efforts, infrastructure improvements, and analysis of gene function annotations.

Mapping molecular determinants of Cav2.2 inhibition by RGK proteins and homologs in Xenopus oocytes

This study identifies structural determinants in RGK proteins that inhibit CaV2.2 channels in Xenopus oocytes, showing key regions in the G-domain and C-terminus are critical for this inhibition.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

Whole-Genome Sequence of African Swine Fever Virus isolate from India provides insights into diversity and evolution

The paper reports the whole-genome sequence of an African swine fever virus isolate from India and compares it to other ASFV genomes to study genetic diversity and evolution.

SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion

This study analyzes the Omicron variant's ACE2 binding and antibody evasion using Cryo-EM and neutralization assays, finding similar ACE2 binding affinity to Delta and increased antibody evasion.

Emerging SARS-CoV-2 Variants of Concern: Spike Protein Mutational Analysis and Epitope for Broad Neutralization

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding

The paper analyzes mutations in the SARS-CoV-2 receptor binding domain to understand their effects on ACE2 and antibody binding in variants of concern.

Structural and Biochemical Rationale for Enhanced Spike Protein Fitness in Delta and Kappa SARS-CoV-2 Variants

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

This paper uses proteomics to analyze platelet changes in SARS-CoV-2-infected humanized mice, finding early activation of coagulation and complement pathways.

Cryo-EM reveals disrupted human p97 allosteric activation by disease mutations and inhibitor binding

This study uses cryo-EM to analyze disease mutations and inhibitor binding in p97, revealing how these affect allosteric activation and provide insights into their mechanistic link to dysfunction.

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

This study characterizes the structure and function of TMPRSS2, a protease involved in SARS-CoV-2 activation, and identifies features for developing selective inhibitors.

Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

This study evaluates T-cell and antibody immunity to SARS-CoV-2 in transplant recipients, finding impaired responses and increased CMV co-infection risk post-infection.

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.

Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry

This study shows that two anti-HIV-1 antibodies bind SARS-CoV-2 spike glycoprotein but do not neutralize it or mediate ADE.

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

This study identifies how EGFR differentiates signaling outputs from EGF and TGF- through conformational changes in its extracellular domain.

Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.

This study reconstitutes the β-adrenergic regulation of CaV1.2 channels in a heterologous system, identifying Rad-dependent and Rad-independent PKA mechanisms.

SUMO Modifies GβL and Mediates mTOR Signaling

This study identifies SUMO modification of GβL as a regulator of mTOR complex assembly and activity, showing that SUMOylation is essential for proper mTOR signaling.

Rhes, a Striatal Enriched Protein, Regulates Post-Translational Small-Ubiquitin-like-Modifier (SUMO) Modification of Nuclear Proteins and Alters Gene Expression

This study identifies Rhes as a regulator of SUMOylation of nuclear proteins and shows its role in modulating striatal gene expression through SUMO-dependent mechanisms.

Plasmin cascade mediates thrombolytic events in SARS-CoV-2 infection via complement and platelet-activating systems

This study investigates how SARS-CoV-2 infection triggers thrombotic events through the plasmin cascade, linking complement and platelet-activating systems in lung epithelia.

Cdk5 and GSK3β inhibit Fast Endophilin-Mediated Endocytosis

This study identifies Cdk5 and GSK3β as negative regulators of fast Endophilin-mediated endocytosis, showing they suppress the pathway by affecting protein interactions and cargo sorting.

Biochemical and structural analysis reveals the Neurofibromin (NF1) protein forms a high-affinity dimer

This study shows Neurofibromin forms a high-affinity dimer through biochemical and structural analysis, with implications for its function in RAS-MAPK signaling.

Genetic and antigenic variation of foot-and-mouth disease virus during persistent infection in naturally infected cattle and Asian buffalo in India

This study analyzes genetic and antigenic changes in FMDV during persistent infection in cattle and buffalo, finding significant variation and antigenic divergence.

Cryopreservation of Rosa hybrida cv. Helmut Schmidt by PVS2 vitrification method using in vitro fragmented explants (IFEs)

This study reports successful cryopreservation of Rosa hybrida cv. Helmut Schmidt using PVS2 vitrification with in vitro fragmented explants, achieving 43.33% growth recovery through optimized parameters.

Automated methods for 3D Segmentation of Focused Ion Beam-Scanning Electron Microscopic Images

The paper introduces automated methods for 3D segmentation of FIB-SEM images, significantly improving analysis speed compared to manual approaches.