K. Tuttle

SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion

This study analyzes the Omicron variant's ACE2 binding and antibody evasion using Cryo-EM and neutralization assays, finding similar ACE2 binding affinity to Delta and increased antibody evasion.

Emerging SARS-CoV-2 Variants of Concern: Spike Protein Mutational Analysis and Epitope for Broad Neutralization

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

Structural and Biochemical Rationale for Enhanced Spike Protein Fitness in Delta and Kappa SARS-CoV-2 Variants

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding

The paper analyzes mutations in the SARS-CoV-2 receptor binding domain to understand their effects on ACE2 and antibody binding in variants of concern.

Cryo-EM reveals disrupted human p97 allosteric activation by disease mutations and inhibitor binding

This study uses cryo-EM to analyze disease mutations and inhibitor binding in p97, revealing how these affect allosteric activation and provide insights into their mechanistic link to dysfunction.

Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.

JAK1 inhibition blocks lethal sterile immune responses:implications for COVID-19 therapy

JAK1 inhibition prevents lethal immune responses and organ failure in a mouse model of Down syndrome and viral infection.